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21-06-2017 15:34

The guideline "Relapse Prevention Anorexia Nervosa" is now available in English. Its intend is to provide guidance in working with a relapse prevention plan to prevent or early detect r...

01-02-2017 10:44

Prof. dr. Annemarie van Elburg has been appointed as honorary member of the NAE for the many activities she has undertaken in her past two terms as chairman of the NAE. 07-06-2016 16:22

Personality traits and uncertainty as a predictor for eating disorders

Roger Adan

Roger Adan


Since 2002 I am a full professor in molecular pharmacology at the department of neuroscience and pharmacology of the University Medical Center Utrecht and my research is embedded in the Rudolf Magnus Institute of Neuroscience ( We aim at unraveling the genetic and neural pathways underlying eating disorders and obesity. Feeding behavior is a complex behavior that serves to control energy balance of an organism. Homeostatic control over energy balance is challenged by higher brain centers that drive feeding of palatable foods or inhibit feeding in order to loose weight. These disruptions may contribute to development of eating disorders and obesity. Several animal models are used in which anorectic behavior (including hyperactivity) is mimicked or in which animals become obese following exposure to palatable choice diets. Using viral vector technology, genes are either overexpressed or knocked down (RNAi) in these animals, in order to unravel the role of genes in feeding behavior and energy balance. Results from animal experiments are translated into clinical relevance by using a human genetics approach. DNA from eating disorders patients and epidemiological cohorts is available with extensive phenotypic information. This allows to determine genotype-phenotype relationships in humans. Since 2010 I also hold a research position at Rintveld Eating disorders which ensures the translational character of the eating disorder research line.

Contact Information

Department Neuroscience and Pharmacology
Section coordinator: Section Neurobiology of behavior
Rudolf Magnus Institute of Neuroscience
Universiteitsweg 100
3584 CG Utrecht
The Netherlands

Tel +31 887568810


Click here to view my published articles.

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